Two patients with post-traumatic osteolysis of the distal end of the c
lavicle undergoing surgery 5 months and 22 months respectively after t
he initial trauma were evaluated histopathologically. The lysed zone w
as replaced by tissue of fibrous appearance, with little blood supply
and non-inflammatory, the presence of which could be suspected by magn
etic resonance. The synovial menbrane, non-inflammatory but hypervascu
larised, participated in the process but did not appear to be directly
responsible for the osteolysis. The osseous tissue of the patient, op
erated upon early, showed signs of osteoclastic resorption but there w
as neither stasis, vasodilatation nor signs of osteogenesis. These var
ious findings suggest that post-traumatic osteolysis of the distal end
of the clavicle does not result from local ischemic events. These app
earances seem identical to those described in multifocal primary osteo
lysis, the cause of which also remains unknown.