EFFECTS OF SETTING ON THE SUBJECTIVE AND BEHAVIORAL-EFFECTS OF D-AMPHETAMINE IN HUMANS

The effects of setting on the subjective and behavioral effects of 20 mg oral d-amphetamine were studied in eight healthy volunteers. A with in-subjects design was used in which subjects ingested either amphetam ine or placebo capsules in either an inpatient (isolated laboratory ro om) or an outpatient (normal daily environment) setting. The order of the four experimental conditions was randomized across subjects. Subje ctive drug effects were assessed using the Profile of Mood States, the Addiction Research Center Inventory, a Visual Analogue Scale, and a D rug Effects/Liking questionnaire, completed prior to and 1,3, and 6 h after capsule ingestion. In addition, an End-of-Session questionnaire measuring overall drug liking and drug identification was completed at the 6-h timepoint. Subjects wore wrist monitors to record their physi cal activity levels during the 6-h postingestion period. Amphetamine p roduced typical stimulant-like subjective effects such as elation, eup horia, and friendliness, but the setting neither quantitatively nor qu alitatively altered the drug response.