STRESS-ULCER PROPHYLAXIS - A REAPPRAISAL OF GASTRIC-ACID SUPPRESSION

Gastric acid suppression with antacids or histamine H-2-blockers is cu rrently the mainstay for the prophylaxis of stress-related gastric muc osal hemorrhage. This practice should be re-evaluated in view of recen t findings about the role of gastric acid in maintaining the sterility of the stomach and proximal intestinal tract. The risks associated wi th bacterial colonization of the upper gastrointestinal tract from aci d suppression and the availability of effective alternative therapy sh ould discourage the use of antacids and histamine H-2-blockers.