INVOLVEMENT OF SEROTONERGIC MECHANISMS IN THE INHIBITORY EFFECT OF U-50, 488H ON GLUTAMATE-INDUCED LETHALITY IN MICE

Authors
KAMEI J IGARASHI H KASUYA Y
Citation
J. Kamei et al., INVOLVEMENT OF SEROTONERGIC MECHANISMS IN THE INHIBITORY EFFECT OF U-50, 488H ON GLUTAMATE-INDUCED LETHALITY IN MICE, Research communications in chemical pathology and pharmacology, 75(3), 1992, pp. 357-360
Citations number
19
Journal title
Research communications in chemical pathology and pharmacology → ACNP
ISSN journal
00345164
Volume
75
Issue
3
Year of publication
1992
Pages
357 - 360
Database
ISI
SICI code
0034-5164(1992)75:3<357:IOSMIT>2.0.ZU;2-X
Abstract
The present study showed the involvement of serotonergic mechanisms in the protective effect of U-50,488H, a selective agonist of kappa-opio id receptors, against glutamate-induced lethality in mice. U-50,488H ( 1 - 10 mg/kg, i.p.) protected mice to a significant extent against glu tamate-induced lethality, in a dose-related manner. This protective ef fect was not observed in p-chlorophenylalanine- or methysergide-treate d mice. These results suggested that 5-HT in the brain may play an imp ortant role in the protective effect of U-50,488H against glutamate-in duced lethality.