ROBUSTNESS OF THE NO-INTERFERENCE MODEL FOR ORDERING GENETIC-MARKERS

Authors
SPEED TP MCPEEK MS EVANS SN
Citation
Tp. Speed et al., ROBUSTNESS OF THE NO-INTERFERENCE MODEL FOR ORDERING GENETIC-MARKERS, Proceedings of the National Academy of Sciences of the United Statesof America, 89(7), 1992, pp. 3103-3106
Citations number
9
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
89
Issue
7
Year of publication
1992
Pages
3103 - 3106
Database
ISI
SICI code
0027-8424(1992)89:7<3103:ROTNMF>2.0.ZU;2-C
Abstract
Under the assumption of no chromatid interference, we derive constrain ts on the probabilities of the different recombination patterns among m + 1 genetic loci. An application of these constraints is a proof tha t the ordering of the loci that maximizes the likelihood under the ass umption of no interference is, in fact, a consistent estimator of the true order even when there is interference.