DIETARY GLUCOSE AND FAT ATTENUATE EFFECTS OF ADRENALECTOMY ON ENERGY-BALANCE IN OB OB MICE/

The body energy balance response of ob/ob mice to adrenalectomy is die t dependent. Diets varying in source of carbohydrate (starch, glucose or fructose), fat to starch ratio, or fat to glucose ratio were fed to determine influences on energy balance in female adrenalectomized ob/ ob mice. Adrenalectomy lowered food intake in all ob/ob mice to values comparable to those of lean mice independent of diet, but the percent age of dietary energy retained as body energy in adrenalectomized ob/o b mice was lowered to values comparable to those of lean mice only in mice fed starch or fructose, not in mice fed glucose or fat. Consumpti on of either high glucose or high fat diets blocked about one-half the overall effect of adrenalectomy on energy balance in ob/ob mice. Hype rinsulinemia was associated with the high efficiency of energy retenti on observed in adrenalectomized ob/ob mice fed glucose, but high effic iency of energy retention occurred in adrenalectomized ob/ob mice fed high fat diets without concomitant hyperinsulinemia. Adrenalectomy-ind uced changes in brain weight and protein content, body protein content and plasma thyroid hormone concentrations in ob/ob mice were independ ent of diet consumption. Combined adrenalectomy-ovariectomy diminished , but did not eliminate, the diet-dependent influences on energy balan ce in ob/ob mice. In conclusion, dietary glucose and dietary fat both attenuate effects of adrenalectomy on energy balance in ob/ob mice by promoting high efficiencies of energy retention.