O-INSERTION INTO NONACTIVATED C-H BONDS - THE 1ST OBSERVATION OF O2 CLEAVAGE BY A P-450 ENZYME MODEL IN THE PRESENCE OF A THIOLATE LIGAND

Authors
PATZELT H WOGGON WD
Citation
H. Patzelt et Wd. Woggon, O-INSERTION INTO NONACTIVATED C-H BONDS - THE 1ST OBSERVATION OF O2 CLEAVAGE BY A P-450 ENZYME MODEL IN THE PRESENCE OF A THIOLATE LIGAND, Helvetica Chimica Acta, 75(2), 1992, pp. 523-530
Citations number
27
Journal title
Helvetica Chimica Acta → ACNP
ISSN journal
0018019X
Volume
75
Issue
2
Year of publication
1992
Pages
523 - 530
Database
ISI
SICI code
0018-019X(1992)75:2<523:OINCB->2.0.ZU;2-8
Abstract
On reaction with 'O'-donors or O2, the synthetic P-450 analogue 2 unde rgoes O-insertion at a nonactivated C-H bond of the covalently bound s ubstrate. The mechanism of O-insertion with O2 most likely involves ho molytic cleavage of the O-O bond followed by O-insertion via radical r ecombination.