Three patients with a soft tissue tumor (STT) exhibiting the very pecu
liar histologic features typical of myxosarcoma are described. Patient
s were 50 years of age. The epidemiology, origin, histologic classific
ation and oncologic staging of STTs are reviewed. The term myxoid refe
rs to a well-defined type of ground substance with typical histochemic
al and cytological characteristics. When feasible, conservative surger
y followed by radiotherapy is the treatment of choice. Adjunctive chem
otherapy is sometimes disappointing.