COMPARATIVE INVITRO ACTIVITY OF SPARFLOXACIN (AT-4140, RP-64206-SPFX)AGAINST 275 MULTIRESISTANT CLINICAL ISOLATES

The in-vitro activity of sparfloxacin was compared with that of peflox acin, ofloxacin, ciprofloxacin, imipenem, ceftazidime, gentamicin and amikacin against 275 multiresistant nosocomial clinical isolates. They consisted of Pseudomonas aeruginosa (37), Enterobacter cloacae (42), Acinetobacter anitratus (60), Klebsiella pneumoniae (37) and Staphyloc occus sp (99). Minimum inhibitory concentrations (MIC90) and geometric mean MICs for sparfloxacin were as follows (mg/l): P. aeruginosa 128 - 23.7, E. cloacae 1 - 0.13, A. anitratus 2 - 0.14, K. pneumoniae 1 - 0.08, MRSA 16 - 0.98, MSSA 0.12 - 0.03, MRSE 0.25 - 0.12 and MSSE 0.12 - 0.05. It is concluded that sparfloxacin was the most potent agent a gainst staphylococci and A. anitratus including strains resistant to t he other quinolones while ciprofloxacin was the most potent agent agai nst P. aeruginosa, E. cloacae and K. pneumoniae.