AZTREONAM VERSUS COLISTIN-NEOMYCIN FOR SELECTIVE DECONTAMINATION OF THE DIGESTIVE-TRACT IN PATIENTS UNDERGOING BONE-MARROW TRANSPLANTATION - A RANDOMIZED STUDY

Aztreonam (Az), a minimally absorbable monobactam antibiotic, was comp ared to colistin plus neomycin (CN), for intestinal decontamination du ring Bone Marrow Transplantation (BMT) in a controlled study. Thirty-f our consecutive patients were randomized in two groups and evaluated f or number of febrile episodes, days of fever, fecal cultures and clini cal symptoms related to infections or colonizations. No significant di fferences were observed suggesting that Az is at least as effective as the CN regimen and may be considered as an alternative approach for i ntestinal decontamination in BMT patients.