EWINGS-SARCOMA - EXPERIENCE WITH 12 CASES

Twelve patients with localized Ewing's sarcoma were treated between 19 80-1990 at the Istanbul School of Medicine, Department of Pediatric On cology-Hematology, Oncology Research and Treatment Center and Our Chil dren Leukemia Foundation. There were 8 boys and 4 girls, with a mean a ge of 8.1 (range 3-17) years. The tumors were in the femur in 3 patien ts, in the humerus and rib in 2 patients each and in the tibia, radius , vertebra, clavicula and pelvis in 1 patient each. Chemotherapy alone was applied in 2 patients, 1 patient had chemotherapy and radiotherap y. The remaining 9 cases were treated with Chemotherapy and radiothera py (during the chemotherapy). The chemotherapy protocols were: VAC (n = 5), VACA (n = 3), IVAD (n = 3) and T.9 (n = 1). One patient died fro m the disease itself. Remissions were achieved in the other 11 patient s. After 5 to 95 months (mean: 22 months) 7 patients had relapsed (4 h ad local and 3 had distant metastases). Three patients were not able t o be followed, 3 died due to additional problems (infection, cardiotox icity). The best prognosis was achieved when Ewing's sarcoma initiated in the long bones, with less than 100 ml tumor volumes and patients w ere under 5 years old. There were no significant differences among che motherapy protocols.