RELATIONSHIP BETWEEN DIETARY-FAT AND EXPERIMENTAL MAMMARY TUMORIGENESIS - A REVIEW AND CRITIQUE

That dietary fat can significantly affect mammary tumorigenesis in mic e and rats has been clearly established. The purpose of this communica tion is to review and critique this interesting and potentially import ant relationship. This review focuses on the relationship between the amount and type of dietary fat and the role of calories in rodent mamm ary tumor development and metastasis. Additionally, the influence of d ietary fat on development of human breast carcinoma transplants in imm unodeficient mice is examined. The numerous studies cited in this revi ew provide a compelling biological foundation for a potentially import ant relationship between dietary fat and/or calorie consumption and br east carcinoma development in human populations.