POSITIVE COOPERATIVITY IN THE FUNCTIONING OF MOLECULAR CHAPERONE GROEL

Authors
BOCHKAREVA ES LISSIN NM FLYNN GC ROTHMAN JE GIRSHOVICH AS
Citation
Es. Bochkareva et al., POSITIVE COOPERATIVITY IN THE FUNCTIONING OF MOLECULAR CHAPERONE GROEL, The Journal of biological chemistry, 267(10), 1992, pp. 6796-6800
Citations number
30
Journal title
The Journal of biological chemistry → ACNP
ISSN journal
00219258
Volume
267
Issue
10
Year of publication
1992
Pages
6796 - 6800
Database
ISI
SICI code
0021-9258(1992)267:10<6796:PCITFO>2.0.ZU;2-4
Abstract
In the presence of its partner, GroES, the tetradecameric molecular ch aperone GroEL binds 14 ATP molecules, half of which are hydrolyzed in a cooperative manner. Moreover GroEL can bind, with a positive coopera tivity, more than two molecules of nonfolded protein rhodanese. The ro le of the cooperative mechanism in the functioning of GroEL is discuss ed.