TUBEROINFUNDIBULAR DOPAMINERGIC-NEURONS AND LACTOTROPES IN YOUNG AND OLD FEMALE RATS

Aging in female rats is accompanied by several endocrine dysfunctions, such as reproductive decline associated with characteristic hyperprol actinemia, lactotrope hyperplasia, and functional impairment of hypoth alamic tuberoinfundibular dopaminergic (TIDA) neurons. The aim of this morphometrical, immunocytochemical, and densitometrical study was to gain a better anatomical knowledge of TIDA neurons and axons as well a s of lactotropes in old female rats with (A) or without (NA) pituitary adenomas, compared with young animals. At the hypothalamic level, we found that tyrosine hydroxylase (TH)-labeled neurons in the arcuate nu cleus were comparable in young and old NA yet their size and TH-conten t were increased in A animals. Also the TH-labeled median eminence axo ns did not differ significantly between young and old NA but were more numerous in the old A rats. Independently from adenomas, both number of prolactin (PRL)-labeled structures and content of immunoreactive PR L were increased in pituitaries of old rats, the plasma PRL levels, ho wever, were high only in A. Our findings support the documented lactot rope hypertrophy and hyperplasia in old female rats and suggest that T IDA-neuron changes only occur in hyperprolactinemic animals carrier of adenomas.