GENETICS OF OTOSCLEROSIS

Authors
SABITHA R RAMALINGAM R RAMALINGAM KK SIVAKUMARAN TA RAMESH A
Citation
R. Sabitha et al., GENETICS OF OTOSCLEROSIS, Journal of Laryngology and Otology, 111(2), 1997, pp. 109-112
Citations number
15
Categorie Soggetti
Otorhinolaryngology
Journal title
Journal of Laryngology and Otology → ACNP
ISSN journal
00222151
Volume
111
Issue
2
Year of publication
1997
Pages
109 - 112
Database
ISI
SICI code
0022-2151(1997)111:2<109:GOO>2.0.ZU;2-5
Abstract
Otosclerosis is an early-middle adult life genetic disease affecting b one remodelling in the ear. Current knowledge of otosclerosis as an in herited disease dates to the mid-19th century, and we report here an a ttempt to understand the genetics of otosclerosis and detect its heter ogeneity. The analysis was conducted on 151 otosclerotic families. The results of our study indicate that while heredity plays an important role in the manifestation of the disease a substantial portion of otos clerotic cases could arise due to non-genetic causes.