Described for the first time about thirty years ago, the Rett syndrome
was since that time the subject of a vast number of scientific works
but its pathogenesis remains puzzling. Rett syndrome has been classifi
ed by the, WHO among rite pervasive developmental disorders. Autistic
disorder represents one of the main differential diagnosis of the init
ial clinical stages. A genetic determination seems probable. The progr
ess in the knowledge of neurodevelopment have recently open Icp intere
sting prospects for the research.