EFFECT OF FLUVASTATIN SODIUM (XU62-320), A NEW INHIBITOR OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE, ON THE INDUCTION OF LOW-DENSITY-LIPOPROTEIN RECEPTOR IN HEPG2 CELLS

Authors
HAYASHI K KUROKAWA J NOMURA S KUGA Y OHKURA Y KAJIYAMA G
Citation
K. Hayashi et al., EFFECT OF FLUVASTATIN SODIUM (XU62-320), A NEW INHIBITOR OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE, ON THE INDUCTION OF LOW-DENSITY-LIPOPROTEIN RECEPTOR IN HEPG2 CELLS, Biochimica et biophysica acta, 1167(2), 1993, pp. 223-225
Citations number
10
Journal title
Biochimica et biophysica acta → ACNP
ISSN journal
00063002
Volume
1167
Issue
2
Year of publication
1993
Pages
223 - 225
Database
ISI
SICI code
0006-3002(1993)1167:2<223:EOFS(A>2.0.ZU;2-U
Abstract
The effect of fluvastatin sodium (XU62-320), a new type of inhibitor o f 3-hydroxy-3-methylglutaryl coenzyme A, on the induction of LDL recep tor in the human liver-derived cell line HepG2 was investigated. Fluva statin sodium produced marked inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and induction of LDL receptor on HepG2 cells at a concentration of 0.1-1.0 muM. These results suggest that fl uvastatin sodium has potential for use as a strong plasma cholesterol- lowering drug.