DIFFERENTIAL-EFFECTS OF KINDLING AND KINDLED SEIZURES ON PLACE LEARNING IN THE MORRIS WATER MAZE

There is some controversy about the role of long-term potentiation (LT P) in spatial learning. The authors have found that triggering general ized kindled seizures with stimulation of the perforant path disrupts spatial learning in the Morris water maze but that kindling per se doe s not affect spatial learning. It is suggested that abnormal electrica l activity induced by high-frequency stimulation of the perforant path may have been responsible for the disruption of spatial learning prev iously attributed to LTP saturation.