DETERMINATION OF RARE-EARTH AND OTHER TRACE-ELEMENT ABUNDANCES IN HUMAN KIDNEY-STONES AND BRAIN-TISSUE BY INSTRUMENTAL NEUTRON-ACTIVATION ANALYSIS

We have used INAA to analyze more than 30 minor and trace elements in 10 human kidney stones (phosphate and oxalate types). In addition we a lso analyzed human brain tissue samples for trace elements by INAA to determine the limitations of the method. Samples were taken from the t emporal and frontal cortex of the brain of a patient that suffered fro m dialysis encephalopathy (where an increased Al content is expected), as well as a number of control samples. Trace elements were analyzed to study possible compositional differences other than the Al content. The analyses were done using large volume HPGe detectors; because of the low abundances, accuracy and precision vary between 3-80% for indi vidual elements. We found a difference between the rare earth element (REE) patterns for apatite and oxalate kidney stones, and a fractionat ion compared to typical REE contents in plants. For the brain samples there is evidence for differences between the dialysis patient and the control samples not only for Al, but also for some other elements inc luding the REEs, but most differences are minimal, and may not be sign ificant.