COMBINED DIRECTED METALATION - CROSS COUPLING STRATEGIES - A REGIOSPECIFIC ROUTE TO HETERORING-ANNELATED ORTHO-NAPHTHOQUINONES AND A SHORT SYNTHESIS OF BETA-LAPACHONE

Authors
BRANDAO MAF DEOLIVEIRA AB SNIECKUS V
Citation
Maf. Brandao et al., COMBINED DIRECTED METALATION - CROSS COUPLING STRATEGIES - A REGIOSPECIFIC ROUTE TO HETERORING-ANNELATED ORTHO-NAPHTHOQUINONES AND A SHORT SYNTHESIS OF BETA-LAPACHONE, Tetrahedron letters, 34(15), 1993, pp. 2437-2440
Citations number
27
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
15
Year of publication
1993
Pages
2437 - 2440
Database
ISI
SICI code
0040-4039(1993)34:15<2437:CDM-CC>2.0.ZU;2-W
Abstract
A general combined metalation - cross coupling methodology (Scheme 1) for the regiospecific construction of heteroring fused o-naphthoquinon es 8 is described and its application to a short synthesis of the anti malarial/antitumor natural product beta-lapachone (14) is demonstrated .