EFFECT OF TOCOTRIENOL ON THE ACTIVITIES OF CYTOSOLIC GLUTATHIONE-DEPENDENT ENZYMES IN RATS TREATED WITH 2-ACETYLAMINOFLUORENE

The effect of tocotrienol on the activities of glutathione S-transfera ses (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx ) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were signif icantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (c u-OOH) was increased but activity assayed with H2O2 was reduced. Suppl ementation of the diet with tocotrienol in the AAF-treated rats reduce d the increase in enzyme activities. Tocotrienol on its own had no eff ect on the enzyme activities.