Objective The authors present an accurate and comprehensive snapshot o
f appendicitis and the practice of appendectomy in the 1990s. Methods
Appendectomies were performed on 4950 patients in 147 Department of De
fense hospitals worldwide over a 12-month period ending January 31, 19
93. Results The median age was 23 years (range, 6 months to 82 years)
with 64% males and 36% females. The patients were assigned a diagnosis
of normal appendix in 632 (13%) cases, acute appendicitis in 3286 (66
%) cases, and perforated appendicitis in 1032 (21%) cases. There were
no differences in perforation and normal appendix rates between those
operations performed in teaching hospitals versus community hospitals
or between high-volume hospitals (greater than or equal to 100 appende
ctomies/year) versus low-volume hospitals. Both a preoperative tempera
ture greater than or equal to 100.5 and a preoperative leukocyte count
greater than or equal to 10,000 were incapable of discriminating betw
een patients with appendicitis and those with a normal appendix. Multi
variate analysis showed a significantly increased risk of perforation
associated with age younger than or equal to 8 years (38% vs. 18%) and
age older than or equal to 45 years (49% vs. 18%). Females had a sign
ificantly higher rate of normal appendices (19% vs. 9%) and a lower ra
te of perforation (18% vs. 23%). The complication rates to include reo
peration and intraabdominal sepsis were markedly increased in those pa
tients with perforation. There were four deaths in this series (0.08%)
. Conclusions Despite a marked decline in associated mortality over th
e past 50 years, rates of perforation and negative appendectomy remain
unchanged because they are influenced strongly by factors untouched b
y the intervening technologic advances.