A. Fang et al., SECONDARY METABOLISM IN SIMULATED MICROGRAVITY - BETA-LACTAM PRODUCTION BY STREPTOMYCES-CLAVULIGERUS, Journal of industrial microbiology & biotechnology, 18(1), 1997, pp. 22-25
Rotating bioreactors designed at NASA's Johnson Space Center were used
to simulate a microgravity environment in which to study secondary me
tabolism, The system examined was p-lactam antibiotic production by St
reptomyces clavuligerus, Both growth and p-lactam production occurred
in simulated microgravity, Stimulatory effects of phosphate and L-lysi
ne, previously detected in normal gravity, also occurred in simulated
microgravity, The degree of p-lactam antibiotic production was markedl
y inhibited by simulated microgravity.