Aim: To determine whether orally delivered instructions can modify the
intensity and direction of blood pressure and heart rate fluctuation.
Methods: The blood pressure of 120 subjects, 60 hypertensive and 60 n
ormotensive, was measured before and after oral instructions. The norm
otensive subjects were selected from a sample of university students a
nd the hypertensive patients were selected at a routine medical screen
ing. Each sample of 60 subjects was randomly divided into four groups
of 15. Each subject was left seated alone in a room for 5 min. The res
earcher then measured the subjects' blood pressure and heart rate. Fol
lowing this, each group of normotensives and hypertensives was told th
at their blood pressure would diminish, or that it would not change or
that it would increase. The control group was given no instructions.
After 5 min the blood pressure and heart were measured again. Results:
In the normotensive and hypertensive groups who were told that their
blood pressure would increase, systolic blood pressure increased by 4.
3 and 2.5 mmHg, respectively. In the groups who were told that their b
lood pressure would decrease, systolic pressure fell by 7.8 and 7.4 mm
Hg, respectively. Those who were told that no change would occur showe
d a systolic pressure decrease of 3.5 and 1.8 mmHg, respectively. In t
he control groups systolic blood pressure decreased by 5.6 and 4.2 mmH
g, respectively. Conclusions: These results show that oral instruction
s are a source of variation in the assessment of blood pressure and em
phasize the need for 24-h blood pressure monitoring to eliminate this
type of variation.