THE ROLES OF CD8 IN CYTOTOXIC T-LYMPHOCYTE FUNCTION

Authors
OROURKE AM MESCHER MF
Citation
Am. Orourke et Mf. Mescher, THE ROLES OF CD8 IN CYTOTOXIC T-LYMPHOCYTE FUNCTION, Immunology today, 14(4), 1993, pp. 183-188
Citations number
50
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
14
Issue
4
Year of publication
1993
Pages
183 - 188
Database
ISI
SICI code
0167-5699(1993)14:4<183:TROCIC>2.0.ZU;2-2
Abstract
The CD8 glycoprotein of cytotoxic T cells is both an adhesion protein and a cosignalling receptor. These functions are regulated by signals from the T-cell antigen receptor complex (TCR-CD3), and CD8 acts to co uple TCR occupancy to second messenger pathways. Here Anne O'Rourke an d Matthew Mescher examine the roles of CD8 in activating the adhesion and signalling cascade initiated by antigen binding.