THE STEPWISE SYNTHESIS OF OLIGO(GLYCOSYL PHOSPHATES) VIA GLYCOSYL HYDROGENPHOSPHONATES - THE CHEMICAL SYNTHESIS OF OLIGOMERIC FRAGMENTS FROM HANSENULA-CAPSULATA Y-1842 EXOPHOSPHOMANNAN AND FROM ESCHERICHIA-COLI K51 CAPSULAR ANTIGEN

A stepwise approach has been used in the syntheses of pentamannosyl te traphosphate HO-[-6Man(alpha)-PO4-]4-6Man(alpha)-OMe and tetra(N-acety lglucosaminyl) triphosphate HO-[-3GlcNAc(alpha)-PO4]3-3GlcNAc(beta)-OC 6H4NO2, which are fragments of the yeast and bacteria extracellular ph ospho-glycans. Elongation of the chain was performed with the use of s uitably protected glycosyl hydrogen-phosphonate derivatives for succes sive introduction of glycosyl phosphate residues. Partially protected monosaccharide derivatives and oligomeric blocks served as hydroxylic components.