T. Orliaguet et al., RELATIONS BETWEEN MECKELS CARTILAGE AND THE MORPHOGENESIS OF THE MANDIBLE IN THE HUMAN EMBRYO, Surgical and radiologic anatomy, 15(1), 1993, pp. 41-46
Based on a series of human embryos classified in stages [28], the auth
ors studied the evolution of Meckel's cartilage in its ventral portion
and its relations to the morphogenesis of the mandible. Three stages
appeared particularly important: stage 16, appearance of Meckel's cart
ilage; stage 20, beginning of membranous ossification; and stage 23, e
nd of the embryonic period (8th week). The primitive bony nodule which
develops from the embryonic mesenchyme appears as a double bony layer
forming a groove containing the neurovascular bundle, into which the
dental lamina is also invaginated.