ANTIMETASTATIC ACTIVITY OF BORO-AMINO ACID ANALOG PROTEASE INHIBITORSAGAINST B16BL6 MELANOMA INVIVO

Authors
KINDER DH ELSTAD CA MEADOWS GG AMES MM
Citation
Dh. Kinder et al., ANTIMETASTATIC ACTIVITY OF BORO-AMINO ACID ANALOG PROTEASE INHIBITORSAGAINST B16BL6 MELANOMA INVIVO, Invasion & metastasis, 12(5-6), 1992, pp. 309-319
Citations number
47
Journal title
Invasion & metastasis → ACNP
ISSN journal
02511789
Volume
12
Issue
5-6
Year of publication
1992
Pages
309 - 319
Database
ISI
SICI code
0251-1789(1992)12:5-6<309:AAOBAA>2.0.ZU;2-P
Abstract
Di- and tripeptide boro-amino acid analog protease inhibitors with spe cificity for chymotrypsin and elastase decrease the number of melanoti c foci formed in the lungs of mice in the B16BL6 experimental metastat ic tumor model. These effects were at significantly lower concentratio n than leupeptin or other natural chymotrypsin inhibitors previously r eported. These results support the involvement of elastase and chymotr ypsin in the metastatic process.