SURVIVAL OF HUMAN MONOCLONAL ANTI-RH(O) (D) ANTIBODIES IN THE RHESUS-MONKEY

In vivo half-life of a I-125-labeled human anti-D monoclonal antibody (mAb) and that of I-131-labeled Rh(o)-GAM was assessed in a rhesus mon key injected simultaneously with both reagents. The half-life of the m Ab was 7.9 days, compared to 17 days of Rh(o)-GAM. Survival of the sec ond dose of mAb, given 34 days after the first injection, was identica l to that of the first dose, thus showing that the human mAb did not e licit an immune response. The in vitro produced human mAbs appear to b e an alternative, unlimited source of anti-D antibodies for possible u se in prevention of feto-maternal Rh immunization.