SYNTHESIS OF POTENTIAL ANTI-AIDS AMPHIPHILES - A NEW EFFICIENT ACYLATION OF AMINO-NAPHTHALENE DISULFONIC ACID-DERIVATIVES

Authors
MADELAINEDUPULCH C ESCOULA B RICO I LATTES A
Citation
C. Madelainedupulch et al., SYNTHESIS OF POTENTIAL ANTI-AIDS AMPHIPHILES - A NEW EFFICIENT ACYLATION OF AMINO-NAPHTHALENE DISULFONIC ACID-DERIVATIVES, Synthetic communications, 23(7), 1993, pp. 949-960
Citations number
15
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
23
Issue
7
Year of publication
1993
Pages
949 - 960
Database
ISI
SICI code
0039-7911(1993)23:7<949:SOPAA->2.0.ZU;2-6
Abstract
We describe a new synthetic route to amphiphilic derivatives of naphth alene disulfonic acid which have been found to be active against HIV-1 and HIV-2. The compounds were obtained in good yield by a new efficie nt acylation of amino-naphthalene disulfonic acid using N-acyl-thiazol idine-2-thiones as acylating agents.