METABOLIC BASIS FOR MANAGEMENT OF THE SEPTIC SURGICAL PATIENT

The physiologic events accompanying postoperative septic complications in surgical patients represent a coordinated response to bacterial in vasion, which is aimed at maintaining the function of key organ system s. When sepsis is prolonged or overwhelming, physiologic dysfunction a nd multi-organ failure develop. This review outlines the pathophysiolo gic response to sepsis and correlates it with recent therapeutic advan ces in the metabolic management of the postoperative septic patient.