L. Mariani et al., CERVICAL-CARCINOMA IN YOUNG-PATIENTS - CLINICAL AND PATHOLOGICAL VARIABLES, International journal of gynaecology and obstetrics, 41(1), 1993, pp. 61-66
Twenty-five (10.2%) out of 243 untreated patients with invasive cervic
al carcinoma were 35 years old or younger. When matching the clinical
and pathological variables between the younger and the older women, th
e former were characterized by a higher rate of Stage IB disease (P =
0.10), G3 and G4 tumors (P = 0.25), bulky lesions (P = 0.05) and node
metastases (P = 0.50). In spite of this poorer pathological profile, b
oth the 5-year disease-free survival rate (75%) and survival according
to stage of the younger women were similar to those reported in large
r series, regardless of the patients' age. No modification of the stan
dard therapy is therefore required in younger patients.