Potential relationships between increased platelet aggregability and s
uch psychological characteristics as hostility and anger were investig
ated as part of a larger intervention study investigating the potentia
l efficacy of stress-reduction treatments. Participants performed 6-mi
nute mental arithmetic tests under time pressure. Blood was sampled du
ring the first minute of the task and whole blood platelet aggregation
was measured in an aggregometer using collagen and ADP. To assess ang
er and hostility, the authors used Spielberger's State-Trait Anger and
Anger Expression scales together with the Cook-Medley Hostility Scale
. The authors found positive correlations between collagen-induced pla
telet aggregation and outwardly expressed anger, as measured by the An
ger Expression Scale. The findings suggested that modes of anger expre
ssion may be associated with increased platelet aggregation. If confir
med by future studies, this finding could provide a mechanism for the
putative connection between anger/hostility and coronary heart disease
.