TOWARDS THE SYNTHESIS OF HIV-PROTEASE INHIBITORS - SYNTHESIS OF OPTICALLY PURE 3-CARBOXYL-DECAHYDROISOQUINOLINES

Authors
HOUPIS IN MOLINA A REAMER RA LYNCH JE VOLANTE RP REIDER PJ
Citation
In. Houpis et al., TOWARDS THE SYNTHESIS OF HIV-PROTEASE INHIBITORS - SYNTHESIS OF OPTICALLY PURE 3-CARBOXYL-DECAHYDROISOQUINOLINES, Tetrahedron letters, 34(16), 1993, pp. 2593-2596
Citations number
11
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
16
Year of publication
1993
Pages
2593 - 2596
Database
ISI
SICI code
0040-4039(1993)34:16<2593:TTSOHI>2.0.ZU;2-U
Abstract
The synthesis of optically pure decahydroisoquinoline 1, a component o f HIV-protease inhibitors, was accomplished in 30-33% overall yield fr om the readily available optically pure monoacid 4.