FACILE SYNTHESIS OF THE TRICARBONYL SUBUNIT IN THE IMMUNOSUPPRESSANT RAPAMYCIN

Authors
PATTENDEN G TANKARD M CHERRY PC
Citation
G. Pattenden et al., FACILE SYNTHESIS OF THE TRICARBONYL SUBUNIT IN THE IMMUNOSUPPRESSANT RAPAMYCIN, Tetrahedron letters, 34(16), 1993, pp. 2677-2680
Citations number
35
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
16
Year of publication
1993
Pages
2677 - 2680
Database
ISI
SICI code
0040-4039(1993)34:16<2677:FSOTTS>2.0.ZU;2-W
Abstract
A concise synthetic route to the tricarbonyl subunit (3a) in the immun osuppressant rapamycin (2), based on ruthenium-catalysed oxidation of an acetylenic amide precursor (17) is described, viz (17) --> (18) --> (20).