TRANSCRIPTIONAL RESPONSE TO CAMP IN BRAIN - SPECIFIC DISTRIBUTION ANDINDUCTION OF CREM ANTAGONISTS

Citation
B. Mellstrom et al., TRANSCRIPTIONAL RESPONSE TO CAMP IN BRAIN - SPECIFIC DISTRIBUTION ANDINDUCTION OF CREM ANTAGONISTS, Neuron, 10(4), 1993, pp. 655-665
Citations number
56
Journal title
NeuronACNP
ISSN journal
08966273
Volume
10
Issue
4
Year of publication
1993
Pages
655 - 665
Database
ISI
SICI code
0896-6273(1993)10:4<655:TRTCIB>2.0.ZU;2-Z
Abstract
Changes in cAMP levels are often associated with the modulation of neu ronal function. The CREM gene encodes both antagonists and activators of the cAMP-dependent transcriptional response by alternative splicing . CREM transcripts in rat brain show a characteristic pattern of expre ssion, being specific for the inner layer of the cerebral cortex, ante rior thalamus, hippocampus, and hypothalamus. Strikingly, the CREM tra nscripts correspond to the antagonist isoforms in these areas, suggest ing a down-regulatory role for CREM in brain; in contrast, the express ion of CREMtau and CREB activators is more diffuse and generalized. In the supraoptic nucleus, CREM expression is induced after osmotic stim ulus. Importantly, this demonstrates physiological inducibility of CRE M, which is novel within the CRE/ATF family.