INTRAOPERATIVE RADIOTHERAPY FOR GASTRIC ADENOCARCINOMA - 45 CASES

Intra-operative radiation therapy (IORT) is a multidisciplinary approa ch in which residual tumors or tumor beds are directly irradiated duri ng a surgical procedure. To evaluate its efficacy we conducted since 1 985 a prospective study including non metastatic gastric adenocarcinom a treated by surgery, IORT (15 Gy) and post-operative external beam ra diotherapy (44 Gy). Up to now, 45 gastric adenocarcinomas (18 pNO and 27 pN1N2) have been included in the study. Mortality and morbidity rat es were not different from those of surgery alone. Overall 5 year surv ival rate is 59.1% and pN1N2 5 years survival rate is 50.6%. These pro mising results are comparable with those of asian randomized studies w hich demonstrate the possible value of IORT in the treatment of gastri c adenocarcinoma.