The low concentration of hepatitis C virus in the blood of infected pa
tients has made it difficult to detect. Infected patients can now be i
dentified by using more sensitive immunoassays and amplification of vi
ral RNA by the polymerase chain reaction. Nevertheless, the virus rema
ins difficult to eliminate. We present the case of a woman with a hist
ory of autoimmune haemolytic anaemia, thrombocytopenia, and common var
iable immunodeficiency who developed chronic hepatitis.