ULCER RISK-FACTORS - INTERACTIONS BETWEEN HELICOBACTER-PYLORI INFECTION, NONSTEROIDAL USE, AND AGE

PURPOSE: To evaluate the influence of Helicobacter pylori, nonsteroida l anti-inflammatory drug (NSAID) use, tobacco and alcohol use, age, ge nder, ethnic group, and the indication for endoscopy on the frequency of gastric and duodenal ulcers in patients referred for upper endoscop y. PATIENTS AND METHODS: One thousand eighty-eight consecutive patient s without prior antrectomy or active bleeding at endoscopy who were ab le to provide a history were interviewed prior to endoscopy, and antra l biopsies were performed for H. pylori at endoscopy. Variables were t ested for univariate association with duodenal or gastric ulcer and th ose variables with p < 0.25 were included in the logistic regression m odel building. RESULTS: One hundred seven patients had duodenal ulcer, 97 had gastric ulcers, and 5 had both. Significant risk factors in th e final model for duodenal ulcer were H. pylori, history of previous u lcer, male gender, bleeding, and pain at presentation (p < 0.001), whe reas alcohol was associated with a decreased risk (p = 0.026). H. pylo ri presence (p = 0.011), aspirin use (p = 0.009), and bleeding (p = 0. 012) were associated with gastric ulcer in the final model; esophageal symptoms were associated with decreased risk of gastric ulcer (p = 0. 003). NSAID use was associated with gastric ulcers only in those over 55 (p < 0.05), especially whites, and in nonwhites without prior ulcer . There was no interaction between H. pylori and NSAIDs. CONCLUSIONS: H. pylori was associated with an increased risk of duodenal and gastri c ulcers. Aspirin increases the risk for gastric ulcer in patients of all ages, whereas nonaspirin, nonsteroidal use increases the risk for gastric ulcers to varying degrees in patients over age 55, depending o n race and history of ulcer.