VISCOSIMETRIC INVESTIGATION OF THE INTERACTION BETWEEN SODIUM DODECYL-SULFATE MICELLES AND A POLYMER DRUG CARRIER

The viscosities of aqueous sodium dodecyl sulfate solutions with and w ithout alpha,beta-poly(N-hydroxyethyl)-DL-aspartamide (PHEA), at 15, 2 5 and 35-degrees-C are reported. The viscosities of SDS and of PHEA aq ueous solutions are discussed in terms of the parameter D [D = (eta/et a0 - 1)/phi] describing the non-ideal behavior of SDS micelles and of PHEA macromolecules. The viscosities of SDS plus PHEA aqueous solution s, discussed in terms of the parameter F [F = eta(rel)(PHEA) + eta(rel )(SDS) - eta(rel)(SDS + PHEA)], demonstrate the occurrence of interact ions between SDS micelles and the PHEA macromolecule. Both D and F are scarcely influenced by temperature variation.