STUDIES ON CURCUMIN AND CURCUMINOIDS .23. EFFECTS OF CURCUMIN ON LIPOSOMAL LIPID-PEROXIDATION

Authors
TONNESEN HH SMISTAD G AGREN T KARLSEN J
Citation
Hh. Tonnesen et al., STUDIES ON CURCUMIN AND CURCUMINOIDS .23. EFFECTS OF CURCUMIN ON LIPOSOMAL LIPID-PEROXIDATION, International journal of pharmaceutics, 90(3), 1993, pp. 221-228
Citations number
25
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
90
Issue
3
Year of publication
1993
Pages
221 - 228
Database
ISI
SICI code
0378-5173(1993)90:3<221:SOCAC.>2.0.ZU;2-8
Abstract
The potential of curcumin as a photosensitzer, radical scavenger and i ron-chelating agent within an artificial membrane (i.e., liposome) is discussed. Curcumin is found to have a dual effect on liposome stabili ty, manifested as peroxidation of phospholipids in the membrane. Curcu min incorporated in the liposomes acts as a chelating agent of ferric and ferrous ions in the membrane.