THE EFFECT OF STORAGE AT AMBIENT HUMIDITY ON THE BET-SPECIFIC SURFACE-AREA OF TABLETS COMPACTED FROM DIFFERENT MATERIALS

Authors
RIEPMA KA DEKKER BG JAGER RS ELBERSE PA LERK CF
Citation
Ka. Riepma et al., THE EFFECT OF STORAGE AT AMBIENT HUMIDITY ON THE BET-SPECIFIC SURFACE-AREA OF TABLETS COMPACTED FROM DIFFERENT MATERIALS, International journal of pharmaceutics, 90(3), 1993, pp. 1-4
Citations number
4
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
90
Issue
3
Year of publication
1993
Pages
1 - 4
Database
ISI
SICI code
0378-5173(1993)90:3<1:TEOSAA>2.0.ZU;2-M
Abstract
Tablets compacted from both water soluble and water insoluble particul ate solids showed no change in BET-specific surface area when transfer red immediately after ejection from the die in a dry atmosphere. Stora ge at ambient humidity resulted in an irreversible decrease in surface area, caused by capillary condensation of moisture and blocking of po res in the tablet. Nitrogen physisorption isotherms performed on cryst alline beta-lactose tablets demonstrated diminution of the mesopore su rface area.