GALANIN-INDUCED GROWTH-HORMONE SECRETION IN CONSCIOUS RATS - EVIDENCEFOR A POSSIBLE INVOLVEMENT OF SOMATOSTATIN

Authors
TANOH T SHIMATSU A ISHIKAWA Y IHARA C YANAIHARA N IMURA H
Citation
T. Tanoh et al., GALANIN-INDUCED GROWTH-HORMONE SECRETION IN CONSCIOUS RATS - EVIDENCEFOR A POSSIBLE INVOLVEMENT OF SOMATOSTATIN, Journal of neuroendocrinology, 5(2), 1993, pp. 183-187
Citations number
35
Journal title
Journal of neuroendocrinology → ACNP
ISSN journal
09538194
Volume
5
Issue
2
Year of publication
1993
Pages
183 - 187
Database
ISI
SICI code
0953-8194(1993)5:2<183:GGSICR>2.0.ZU;2-P
Abstract
Intracerebroventricular administration of galanin (GAL) potently evoke d growth hormone (GH) secretion in conscious male rats. Pretreatments with neostigmine and cysteamine blunted the GAL-induced GH secretion. Pretreatment of animals with a specific anti-somatostatin serum signif icantly inhibited the GAL-induced GH secretion. On the contrary, GH-re leasing hormone-induced GH secretion was significantly enhanced with c ysteamine and anti-somatostatin serum. These results suggest that soma tostatin is involved in GAL-induced GH secretion in rats.