TOXIC SYNDROME AND SUBCUTANEOUS NODULES AS THE ONLY CLINIC MANIFESTATION OF SYSTEMIC SARCOIDOSIS

Sarcoidosis is a systemic disease with frequent cutaneous manifestatio ns. Among these exists a predominance of the so-called unspecific lesi ons because of their histopathological features. Within the specific l esions, that is those which showed non-caseous granulomas, subcutaneou s nodules are underlined, which have been associated with chronic sarc oidosis with a frequency of 1.4%-6%. These lesions appear during the e volution of the disease but rarely constitute an initial manifestation of it. The patient whose case is discussed had a debut with toxic syn drome and subcutaneous nodules. Histopathological study of these nodul es showed the existence of non caseous granulomas formed by histiocyte s, epithelioid cells, Langhans and foreign body giant cells. Lobulet H epatic Granulomas were showed together with mediastinic pulmonar capta tion of Gallium. We conclude that sarcoidosis must be considered when performing the differential diagnosis of the diseases which debut with subcutaneous nodules.