JANTHITREM-B AND JANTHITREM-C, 2 PRINCIPAL INDOLE-DITERPENOIDS PRODUCED BY PENICILLIUM-JANTHINELLUM

The structures of janthitrems B and C, the two most abundant tremorgen ic mycotoxins produced by certain isolates of Penicillium janthinellum from New Zealand and Australia, have been elucidated by NMR spectrosc opy. The compounds differ only by the oxygen atom in janthitrem B at C -22 but closely resemble janthitrems E-F except for dehydration in the terminal isoprene of the diterpenoid moiety. The diterpenoid moiety o f janthitrems B and C is identical to that of penitrem D and generally similar to that of all penitrems.