THE PROBLEM OF ANTIVIRAL THERAPY FOR CHRONIC HEPADNAVIRUS INFECTIONS

Attempts at antiviral therapy of patients with active liver disease as a consequence of chronic hepatitis B virus infection have been modera tely successful. The molecular and cellular basis for a successful out come in these patients is not understood and the same therapies do not appear to benefit carriers that still have fairly normal livers and o nly a moderate hepatitis as a result of the immune response to the inf ection. Most carriers fall into this latter classification, at least d uring the early years of infection, and a therapy that could be succes sfully applied before extensive liver damage had occurred would presum ably reduce the risk of subsequent liver damage and the progression to primary hepatocellular carcinoma. Traditionally, it has been assumed that the primary reason that individuals become chronically infected i s that the cytotoxic T-cell response and/or antibody-dependent killing of infected hepatocytes is insufficient to clear the infection. Less attention has been focused on the role of the antibody response in the generation of virus-neutralizing antibodies as the possible major def iciency predisposing some individuals to become carriers. However, car riers normally are antigenemic for HBsAg and virus, and carriers with only antibodies to these structures in their circulation are virtually unknown. In addition, it is usually assumed that the hepatocyte, the major target of infection, does not spontaneously turn over and that, in the absence of an immune response to the infected cell, hepatocellu lar viability is unaffected. If, however, hepatocytes have a programme d, albeit long, lifetime, then ongoing recruitment of hepatocytes into the infected cell pool may be of major importance in the continuation of a chronic infection. In this review, the possibility is discussed that ongoing extracellular spread of virus infection is a requisite fo r the maintenance of infection in the healthy carrier. The implication s of this model for treatment of these patients are discussed and the results of antiviral therapy in an animal model apparently lacking ant iviral immune reactivity briefly reviewed.