There are relatively few reports of pancreatic disease in cats. In one
survey of 800 feline necropsies, only 28 (3.5%) had gross and/or micr
oscopic evidence of exocrine pancreatic disease. Excluding exocrine pa
ncreatic insufficiency, the history, clinical signs, and results of no
ninvasive diagnostic tests for pancreatic disease are vague and nonspe
cific-probably the major reason that pancreatic disease is diagnosed s
o infrequently in cats. In most cases, a definitive diagnosis is reach
ed only at necropsy. In live animals, exploratory laparotomy (with pan
creatic biopsies taken for histopathologic examination) is likely to y
ield more information than any other test. This article addresses exoc
rine pancreatic insufficiency; pancreatic neoplasia (including apudoma
s); insular amyloidosis; pancreatic flukes; and pancreatic, bladder, a
nd other miscellaneous conditions.