HPLC SEPARATION OF CHIRAL BENZO-1,4-DIAZEPINES

Cyclodextrins as chiral stationary phases (CSP) are useful for chromat ographic separations of racemic analytes, which are able for enantiose lective interactions with the CSP. Studies in this work are reported a nalytical separations of various benzo-1,4-diazepines and the influenc e of temperature on the retention. The fact of ''enantiomerization'' o f oxazepam by the chromatographic process on a beta-cyclodextrin colum n is described.