INHIBITION OF PERIPHERAL FAST SYNAPTIC INPUTS TO CELIAC GANGLION NEURONS BY SPLANCHNIC PREGANGLIONIC FIBERS IN THE CAT

Fast nicotinic transmission was studied in vitro in isolated cat celia c ganglion neurons using intracellular recording techniques. Fast syna ptic activation was evoked by stimulation (0.1 Hz) of the anterior per ipheral rami. A long-lasting inhibition of this response was triggered by repetitive splanchnic stimulation (30-50 Hz) for 10 s. Evidence is given that this inhibition occurs at presynaptic level. Our results i ndicate that central inputs modulate transmission of fast synaptic per ipheral inputs to prevertebral ganglionic neurons. This would be anoth er integrative mechanism in the prevertebral ganglia.