THE EFFECTS OF GLUCOSE ON PLASMA AMINO-ACIDS AND PYRUVATE DURING UPPER ABDOMINAL-SURGERY

To assess the potential benefits of perioperative glucose administrati on, the plasma concentrations of insulin, free fatty acids, ketone bod ies, amino acids, lactate, and pyruvate were measured in 20 patients u ndergoing partial gastrectomy Ten patients received intravenous glucos e at 10 g/h during the operation, and the other 10 patients, as contro l, received no glucose. Plasma glucose, insulin activity, pyruvate and alanine concentrations in the glucose-receiving group increased signi ficantly during the operation in comparison with the control group. In contrast, in the glucose-receiving group the plasma ketone bodies and branched-chain amino acids, especially leucine and isoleucine, decrea sed significantly during surgery. These results suggest that administr ation of glucose stimulated insulin secretion and resulted in accumula tion of the substrates such as pyruvate and alanine which were utilize d readily in the body. Glucose administration is useful in suppressing catabolism during upper abdominal surgery.